Effectiveness of Live Attenuated vs Inactivated Influenza Vaccines in Children During the 2012-2013 Through 2015-2016 Influenza Seasons in Alberta, Canada: A Canadian Immunization Research Network (CIRN) Study.
Identifieur interne : 000055 ( Main/Exploration ); précédent : 000054; suivant : 000056Effectiveness of Live Attenuated vs Inactivated Influenza Vaccines in Children During the 2012-2013 Through 2015-2016 Influenza Seasons in Alberta, Canada: A Canadian Immunization Research Network (CIRN) Study.
Auteurs : Sarah A. Buchan [Canada] ; Stephanie Booth [Canada] ; Allison N. Scott [Canada] ; Kimberley A. Simmonds [Canada] ; Lawrence W. Svenson [Canada] ; Steven J. Drews [Canada] ; Margaret L. Russell [Canada] ; Natasha S. Crowcroft [Canada] ; Mark Loeb [Canada] ; Bryna F. Warshawsky [Canada] ; Jeffrey C. Kwong [Canada]Source :
- JAMA pediatrics [ 2168-6211 ] ; 2018.
Descripteurs français
- KwdFr :
- Adolescent, Alberta, Enfant, Enfant d'âge préscolaire, Femelle, Grippe humaine (), Grippe humaine (virologie), Grippe humaine (épidémiologie), Humains, Mâle, Saisons, Sous-type H1N1 du virus de la grippe A, Sous-type H3N2 du virus de la grippe A, Vaccination (), Vaccins antigrippaux (administration et posologie), Vaccins atténués (administration et posologie), Vaccins inactivés (administration et posologie).
- MESH :
- administration et posologie : Vaccins antigrippaux, Vaccins atténués, Vaccins inactivés.
- virologie : Grippe humaine.
- épidémiologie : Grippe humaine.
- Adolescent, Alberta, Enfant, Enfant d'âge préscolaire, Femelle, Grippe humaine, Humains, Mâle, Saisons, Sous-type H1N1 du virus de la grippe A, Sous-type H3N2 du virus de la grippe A, Vaccination.
English descriptors
- KwdEn :
- Adolescent, Alberta, Child, Child, Preschool, Female, Humans, Influenza A Virus, H1N1 Subtype, Influenza A Virus, H3N2 Subtype, Influenza Vaccines (administration & dosage), Influenza, Human (epidemiology), Influenza, Human (prevention & control), Influenza, Human (virology), Male, Seasons, Vaccination (statistics & numerical data), Vaccines, Attenuated (administration & dosage), Vaccines, Inactivated (administration & dosage).
- MESH :
- chemical , administration & dosage : Influenza Vaccines, Vaccines, Attenuated, Vaccines, Inactivated.
- geographic : Alberta.
- epidemiology : Influenza, Human.
- prevention & control : Influenza, Human.
- statistics & numerical data : Vaccination.
- virology : Influenza, Human.
- Adolescent, Child, Child, Preschool, Female, Humans, Influenza A Virus, H1N1 Subtype, Influenza A Virus, H3N2 Subtype, Male, Seasons.
Abstract
Importance
Recent observational studies report conflicting results regarding the effectiveness of live attenuated influenza vaccine (LAIV), particularly against influenza A(H1N1)pdm09.
Objective
To compare the effectiveness of LAIV and inactivated influenza vaccine (IIV) against laboratory-confirmed influenza.
Design, Setting, and Participants
A test-negative study to estimate influenza vaccine effectiveness (VE) using population-based, linked, individual-level laboratory, health administrative, and immunization data. Data were obtained from 10 169 children and adolescents aged 2 to 17 years (children) who were tested for influenza in inpatient or outpatient settings during periods when influenza was circulating based on a threshold level of 5% weekly test positivity for the province during the 4 influenza seasons spanning from November 11, 2012, to April 30, 2016, in Alberta, Canada. Logistic regression was used to estimate VE by vaccine type, influenza season, and influenza type and subtype. The relative effectiveness of each vaccine type was assessed by comparing the odds of laboratory-confirmed influenza infection for LAIV recipients with that for IIV recipients.
Exposures
The primary exposure was receipt of LAIV or IIV before testing for influenza.
Main Outcomes and Measures
The primary outcome was influenza case status as determined by reverse-transcriptase polymerase chain reaction testing.
Results
A total of 10 779 respiratory specimens (from 10 169 children) collected and tested for influenza during the 4 influenza seasons were included, with 53.4% from males; the mean (SD) age was 7.0 (4.6) years. Across the 4 influenza seasons, 3161 children tested positive for influenza. Combining the 4 influenza seasons, the adjusted VE against influenza A(H1N1)pdm09 was 69% (95% CI, 56%-78%) for LAIV compared with 79% (95% CI, 70%-86%) for IIV. Vaccine effectiveness against influenza A(H3N2) was 36% (95% CI, 14%-53%) for LAIV and 43% (95% CI, 22%-59%) for IIV. Against influenza B, VE was 74% (95% CI, 62%-82%) for LAIV and 56% (95% CI, 41%-66%) for IIV. There were no significant differences in the odds of influenza infection for LAIV recipients compared with IIV recipients except for influenza B during the 2015-2016 season, when LAIV recipients had lower odds of infection than IIV recipients (odds ratio, 0.36; 95% CI, 0.17-0.76).
Conclusions and Relevance
There was no evidence to support the lack of effectiveness of LAIV against influenza A(H1N1)pdm09. These results support administration of either vaccine type in this age group.
DOI: 10.1001/jamapediatrics.2018.1514
PubMed: 29971427
Affiliations:
- Canada
- Alberta, Ontario
- Calgary, Hamilton (Ontario), Toronto
- Université McMaster, Université de Calgary, Université de Toronto
Links toward previous steps (curation, corpus...)
Le document en format XML
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Kwong</name><affiliation wicri:level="4"><nlm:affiliation>Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Primary Care & Population Health Research Program, Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Primary Care & Population Health Research Program, Institute for Clinical Evaluative Sciences, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Applied Immunization Research and Evaluation, Public Health Ontario, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Applied Immunization Research and Evaluation, Public Health Ontario, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:affiliation>Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Family and Community Medicine, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Toronto Western Family Health Team, University Health Network, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Toronto Western Family Health Team, University Health Network, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2018">2018</date><idno type="RBID">pubmed:29971427</idno><idno type="pmid">29971427</idno><idno type="doi">10.1001/jamapediatrics.2018.1514</idno><idno type="wicri:Area/Main/Corpus">000040</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000040</idno><idno type="wicri:Area/Main/Curation">000040</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000040</idno><idno type="wicri:Area/Main/Exploration">000040</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Effectiveness of Live Attenuated vs Inactivated Influenza Vaccines in Children During the 2012-2013 Through 2015-2016 Influenza Seasons in Alberta, Canada: A Canadian Immunization Research Network (CIRN) Study.</title><author><name sortKey="Buchan, Sarah A" sort="Buchan, Sarah A" uniqKey="Buchan S" first="Sarah A" last="Buchan">Sarah A. Buchan</name><affiliation wicri:level="4"><nlm:affiliation>Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Primary Care & Population Health Research Program, Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Primary Care & Population Health Research Program, Institute for Clinical Evaluative Sciences, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Booth, Stephanie" sort="Booth, Stephanie" uniqKey="Booth S" first="Stephanie" last="Booth">Stephanie Booth</name><affiliation wicri:level="1"><nlm:affiliation>Analytics and Performance Reporting Branch, Alberta Ministry of Health, Edmonton, Alberta, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Analytics and Performance Reporting Branch, Alberta Ministry of Health, Edmonton, Alberta</wicri:regionArea><wicri:noRegion>Alberta</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:affiliation>Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta</wicri:regionArea><orgName type="university">Université de Calgary</orgName><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName></affiliation></author><author><name sortKey="Scott, Allison N" sort="Scott, Allison N" uniqKey="Scott A" first="Allison N" last="Scott">Allison N. Scott</name><affiliation wicri:level="1"><nlm:affiliation>Analytics and Performance Reporting Branch, Alberta Ministry of Health, Edmonton, Alberta, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Analytics and Performance Reporting Branch, Alberta Ministry of Health, Edmonton, Alberta</wicri:regionArea><wicri:noRegion>Alberta</wicri:noRegion></affiliation></author><author><name sortKey="Simmonds, Kimberley A" sort="Simmonds, Kimberley A" uniqKey="Simmonds K" first="Kimberley A" last="Simmonds">Kimberley A. Simmonds</name><affiliation wicri:level="4"><nlm:affiliation>Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta</wicri:regionArea><orgName type="university">Université de Calgary</orgName><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Research and Innovation Branch, Alberta Ministry of Health, Edmonton, Alberta, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Research and Innovation Branch, Alberta Ministry of Health, Edmonton, Alberta</wicri:regionArea><wicri:noRegion>Alberta</wicri:noRegion></affiliation></author><author><name sortKey="Svenson, Lawrence W" sort="Svenson, Lawrence W" uniqKey="Svenson L" first="Lawrence W" last="Svenson">Lawrence W. Svenson</name><affiliation wicri:level="1"><nlm:affiliation>Analytics and Performance Reporting Branch, Alberta Ministry of Health, Edmonton, Alberta, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Analytics and Performance Reporting Branch, Alberta Ministry of Health, Edmonton, Alberta</wicri:regionArea><wicri:noRegion>Alberta</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:affiliation>Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta</wicri:regionArea><orgName type="university">Université de Calgary</orgName><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Division of Preventive Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Preventive Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta</wicri:regionArea><wicri:noRegion>Alberta</wicri:noRegion></affiliation></author><author><name sortKey="Drews, Steven J" sort="Drews, Steven J" uniqKey="Drews S" first="Steven J" last="Drews">Steven J. Drews</name><affiliation wicri:level="1"><nlm:affiliation>Diagnostic Virology, Provincial Laboratory (ProvLab) for Public Health, Edmonton, Alberta, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Diagnostic Virology, Provincial Laboratory (ProvLab) for Public Health, Edmonton, Alberta</wicri:regionArea><wicri:noRegion>Alberta</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta</wicri:regionArea><wicri:noRegion>Alberta</wicri:noRegion></affiliation></author><author><name sortKey="Russell, Margaret L" sort="Russell, Margaret L" uniqKey="Russell M" first="Margaret L" last="Russell">Margaret L. Russell</name><affiliation wicri:level="4"><nlm:affiliation>Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta</wicri:regionArea><orgName type="university">Université de Calgary</orgName><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName></affiliation></author><author><name sortKey="Crowcroft, Natasha S" sort="Crowcroft, Natasha S" uniqKey="Crowcroft N" first="Natasha S" last="Crowcroft">Natasha S. Crowcroft</name><affiliation wicri:level="4"><nlm:affiliation>Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Applied Immunization Research and Evaluation, Public Health Ontario, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Applied Immunization Research and Evaluation, Public Health Ontario, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:affiliation>Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Loeb, Mark" sort="Loeb, Mark" uniqKey="Loeb M" first="Mark" last="Loeb">Mark Loeb</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario</wicri:regionArea><orgName type="university">Université McMaster</orgName><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Warshawsky, Bryna F" sort="Warshawsky, Bryna F" uniqKey="Warshawsky B" first="Bryna F" last="Warshawsky">Bryna F. Warshawsky</name><affiliation wicri:level="1"><nlm:affiliation>Communicable Diseases, Emergency Preparedness and Response, Public Health Ontario, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Communicable Diseases, Emergency Preparedness and Response, Public Health Ontario, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Biostatistics, Western University, London, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Western University, London, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Kwong, Jeffrey C" sort="Kwong, Jeffrey C" uniqKey="Kwong J" first="Jeffrey C" last="Kwong">Jeffrey C. Kwong</name><affiliation wicri:level="4"><nlm:affiliation>Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Primary Care & Population Health Research Program, Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Primary Care & Population Health Research Program, Institute for Clinical Evaluative Sciences, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Applied Immunization Research and Evaluation, Public Health Ontario, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Applied Immunization Research and Evaluation, Public Health Ontario, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:affiliation>Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Family and Community Medicine, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Toronto Western Family Health Team, University Health Network, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Toronto Western Family Health Team, University Health Network, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author></analytic><series><title level="j">JAMA pediatrics</title><idno type="eISSN">2168-6211</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Alberta</term><term>Child</term><term>Child, Preschool</term><term>Female</term><term>Humans</term><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza A Virus, H3N2 Subtype</term><term>Influenza Vaccines (administration & dosage)</term><term>Influenza, Human (epidemiology)</term><term>Influenza, Human (prevention & control)</term><term>Influenza, Human (virology)</term><term>Male</term><term>Seasons</term><term>Vaccination (statistics & numerical data)</term><term>Vaccines, Attenuated (administration & dosage)</term><term>Vaccines, Inactivated (administration & dosage)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Alberta</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Grippe humaine ()</term><term>Grippe humaine (virologie)</term><term>Grippe humaine (épidémiologie)</term><term>Humains</term><term>Mâle</term><term>Saisons</term><term>Sous-type H1N1 du virus de la grippe A</term><term>Sous-type H3N2 du virus de la grippe A</term><term>Vaccination ()</term><term>Vaccins antigrippaux (administration et posologie)</term><term>Vaccins atténués (administration et posologie)</term><term>Vaccins inactivés (administration et posologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Influenza Vaccines</term><term>Vaccines, Attenuated</term><term>Vaccines, Inactivated</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Alberta</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Vaccins antigrippaux</term><term>Vaccins atténués</term><term>Vaccins inactivés</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Vaccination</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Child</term><term>Child, Preschool</term><term>Female</term><term>Humans</term><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza A Virus, H3N2 Subtype</term><term>Male</term><term>Seasons</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Alberta</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Grippe humaine</term><term>Humains</term><term>Mâle</term><term>Saisons</term><term>Sous-type H1N1 du virus de la grippe A</term><term>Sous-type H3N2 du virus de la grippe A</term><term>Vaccination</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>Importance</b></p><p>Recent observational studies report conflicting results regarding the effectiveness of live attenuated influenza vaccine (LAIV), particularly against influenza A(H1N1)pdm09.</p></div><div type="abstract" xml:lang="en"><p><b>Objective</b></p><p>To compare the effectiveness of LAIV and inactivated influenza vaccine (IIV) against laboratory-confirmed influenza.</p></div><div type="abstract" xml:lang="en"><p><b>Design, Setting, and Participants</b></p><p>A test-negative study to estimate influenza vaccine effectiveness (VE) using population-based, linked, individual-level laboratory, health administrative, and immunization data. Data were obtained from 10 169 children and adolescents aged 2 to 17 years (children) who were tested for influenza in inpatient or outpatient settings during periods when influenza was circulating based on a threshold level of 5% weekly test positivity for the province during the 4 influenza seasons spanning from November 11, 2012, to April 30, 2016, in Alberta, Canada. Logistic regression was used to estimate VE by vaccine type, influenza season, and influenza type and subtype. The relative effectiveness of each vaccine type was assessed by comparing the odds of laboratory-confirmed influenza infection for LAIV recipients with that for IIV recipients.</p></div><div type="abstract" xml:lang="en"><p><b>Exposures</b></p><p>The primary exposure was receipt of LAIV or IIV before testing for influenza.</p></div><div type="abstract" xml:lang="en"><p><b>Main Outcomes and Measures</b></p><p>The primary outcome was influenza case status as determined by reverse-transcriptase polymerase chain reaction testing.</p></div><div type="abstract" xml:lang="en"><p><b>Results</b></p><p>A total of 10 779 respiratory specimens (from 10 169 children) collected and tested for influenza during the 4 influenza seasons were included, with 53.4% from males; the mean (SD) age was 7.0 (4.6) years. Across the 4 influenza seasons, 3161 children tested positive for influenza. Combining the 4 influenza seasons, the adjusted VE against influenza A(H1N1)pdm09 was 69% (95% CI, 56%-78%) for LAIV compared with 79% (95% CI, 70%-86%) for IIV. Vaccine effectiveness against influenza A(H3N2) was 36% (95% CI, 14%-53%) for LAIV and 43% (95% CI, 22%-59%) for IIV. Against influenza B, VE was 74% (95% CI, 62%-82%) for LAIV and 56% (95% CI, 41%-66%) for IIV. There were no significant differences in the odds of influenza infection for LAIV recipients compared with IIV recipients except for influenza B during the 2015-2016 season, when LAIV recipients had lower odds of infection than IIV recipients (odds ratio, 0.36; 95% CI, 0.17-0.76).</p></div><div type="abstract" xml:lang="en"><p><b>Conclusions and Relevance</b></p><p>There was no evidence to support the lack of effectiveness of LAIV against influenza A(H1N1)pdm09. These results support administration of either vaccine type in this age group.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29971427</PMID><DateCompleted><Year>2019</Year><Month>10</Month><Day>08</Day></DateCompleted><DateRevised><Year>2019</Year><Month>10</Month><Day>08</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2168-6211</ISSN><JournalIssue CitedMedium="Internet"><Volume>172</Volume><Issue>9</Issue><PubDate><Year>2018</Year><Month>09</Month><Day>01</Day></PubDate></JournalIssue><Title>JAMA pediatrics</Title><ISOAbbreviation>JAMA Pediatr</ISOAbbreviation></Journal><ArticleTitle>Effectiveness of Live Attenuated vs Inactivated Influenza Vaccines in Children During the 2012-2013 Through 2015-2016 Influenza Seasons in Alberta, Canada: A Canadian Immunization Research Network (CIRN) Study.</ArticleTitle><Pagination><MedlinePgn>e181514</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1001/jamapediatrics.2018.1514</ELocationID><Abstract><AbstractText Label="Importance">Recent observational studies report conflicting results regarding the effectiveness of live attenuated influenza vaccine (LAIV), particularly against influenza A(H1N1)pdm09.</AbstractText><AbstractText Label="Objective">To compare the effectiveness of LAIV and inactivated influenza vaccine (IIV) against laboratory-confirmed influenza.</AbstractText><AbstractText Label="Design, Setting, and Participants">A test-negative study to estimate influenza vaccine effectiveness (VE) using population-based, linked, individual-level laboratory, health administrative, and immunization data. Data were obtained from 10 169 children and adolescents aged 2 to 17 years (children) who were tested for influenza in inpatient or outpatient settings during periods when influenza was circulating based on a threshold level of 5% weekly test positivity for the province during the 4 influenza seasons spanning from November 11, 2012, to April 30, 2016, in Alberta, Canada. Logistic regression was used to estimate VE by vaccine type, influenza season, and influenza type and subtype. The relative effectiveness of each vaccine type was assessed by comparing the odds of laboratory-confirmed influenza infection for LAIV recipients with that for IIV recipients.</AbstractText><AbstractText Label="Exposures">The primary exposure was receipt of LAIV or IIV before testing for influenza.</AbstractText><AbstractText Label="Main Outcomes and Measures">The primary outcome was influenza case status as determined by reverse-transcriptase polymerase chain reaction testing.</AbstractText><AbstractText Label="Results">A total of 10 779 respiratory specimens (from 10 169 children) collected and tested for influenza during the 4 influenza seasons were included, with 53.4% from males; the mean (SD) age was 7.0 (4.6) years. Across the 4 influenza seasons, 3161 children tested positive for influenza. Combining the 4 influenza seasons, the adjusted VE against influenza A(H1N1)pdm09 was 69% (95% CI, 56%-78%) for LAIV compared with 79% (95% CI, 70%-86%) for IIV. Vaccine effectiveness against influenza A(H3N2) was 36% (95% CI, 14%-53%) for LAIV and 43% (95% CI, 22%-59%) for IIV. Against influenza B, VE was 74% (95% CI, 62%-82%) for LAIV and 56% (95% CI, 41%-66%) for IIV. There were no significant differences in the odds of influenza infection for LAIV recipients compared with IIV recipients except for influenza B during the 2015-2016 season, when LAIV recipients had lower odds of infection than IIV recipients (odds ratio, 0.36; 95% CI, 0.17-0.76).</AbstractText><AbstractText Label="Conclusions and Relevance">There was no evidence to support the lack of effectiveness of LAIV against influenza A(H1N1)pdm09. These results support administration of either vaccine type in this age group.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Buchan</LastName><ForeName>Sarah A</ForeName><Initials>SA</Initials><AffiliationInfo><Affiliation>Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Primary Care & Population Health Research Program, Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Booth</LastName><ForeName>Stephanie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Analytics and Performance Reporting Branch, Alberta Ministry of Health, Edmonton, Alberta, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Scott</LastName><ForeName>Allison N</ForeName><Initials>AN</Initials><AffiliationInfo><Affiliation>Analytics and Performance Reporting Branch, Alberta Ministry of Health, Edmonton, Alberta, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Simmonds</LastName><ForeName>Kimberley A</ForeName><Initials>KA</Initials><AffiliationInfo><Affiliation>Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Research and Innovation Branch, Alberta Ministry of Health, Edmonton, Alberta, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Svenson</LastName><ForeName>Lawrence W</ForeName><Initials>LW</Initials><AffiliationInfo><Affiliation>Analytics and Performance Reporting Branch, Alberta Ministry of Health, Edmonton, Alberta, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Preventive Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Drews</LastName><ForeName>Steven J</ForeName><Initials>SJ</Initials><AffiliationInfo><Affiliation>Diagnostic Virology, Provincial Laboratory (ProvLab) for Public Health, Edmonton, Alberta, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Russell</LastName><ForeName>Margaret L</ForeName><Initials>ML</Initials><AffiliationInfo><Affiliation>Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Crowcroft</LastName><ForeName>Natasha S</ForeName><Initials>NS</Initials><AffiliationInfo><Affiliation>Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Applied Immunization Research and Evaluation, Public Health Ontario, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Loeb</LastName><ForeName>Mark</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Warshawsky</LastName><ForeName>Bryna F</ForeName><Initials>BF</Initials><AffiliationInfo><Affiliation>Communicable Diseases, Emergency Preparedness and Response, Public Health Ontario, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Epidemiology and Biostatistics, Western University, London, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kwong</LastName><ForeName>Jeffrey C</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Primary Care & Population Health Research Program, Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Applied Immunization Research and Evaluation, Public Health Ontario, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Toronto Western Family Health Team, University Health Network, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>09</Month><Day>04</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>JAMA Pediatr</MedlineTA><NlmUniqueID>101589544</NlmUniqueID><ISSNLinking>2168-6203</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007252">Influenza Vaccines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014613">Vaccines, Attenuated</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015164">Vaccines, Inactivated</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>JAMA Pediatr. 2019 Feb 1;173(2):195-196</RefSource><PMID Version="1">30535171</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000416" MajorTopicYN="N" Type="Geographic">Alberta</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053118" MajorTopicYN="N">Influenza A Virus, H1N1 Subtype</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053122" MajorTopicYN="N">Influenza A Virus, H3N2 Subtype</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007252" MajorTopicYN="N">Influenza Vaccines</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" 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PubStatus="medline"><Year>2019</Year><Month>10</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>7</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">29971427</ArticleId><ArticleId IdType="pii">2685843</ArticleId><ArticleId IdType="doi">10.1001/jamapediatrics.2018.1514</ArticleId><ArticleId IdType="pmc">PMC6143060</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Clin Infect Dis. 2016 Dec 15;63(12):1564-1573</Citation><ArticleIdList><ArticleId IdType="pubmed">27702768</ArticleId></ArticleIdList></Reference><Reference><Citation>Vaccine. 2012 Jan 20;30(5):886-92</Citation><ArticleIdList><ArticleId IdType="pubmed">22155144</ArticleId></ArticleIdList></Reference><Reference><Citation>MMWR Morb Mortal Wkly Rep. 2015 Aug 7;64(30):818-25</Citation><ArticleIdList><ArticleId IdType="pubmed">26247435</ArticleId></ArticleIdList></Reference><Reference><Citation>Vaccine. 2016 Feb 17;34(8):1070-6</Citation><ArticleIdList><ArticleId IdType="pubmed">26795366</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2015 Apr 17;10(4):e0122910</Citation><ArticleIdList><ArticleId IdType="pubmed">25885063</ArticleId></ArticleIdList></Reference><Reference><Citation>Euro Surveill. 2016 Sep 22;21(38):</Citation><ArticleIdList><ArticleId IdType="pubmed">27684603</ArticleId></ArticleIdList></Reference><Reference><Citation>J Infect Dis. 2016 Apr 15;213(8):1229-36</Citation><ArticleIdList><ArticleId IdType="pubmed">26597255</ArticleId></ArticleIdList></Reference><Reference><Citation>Vaccine. 2013 Apr 19;31(17):2165-8</Citation><ArticleIdList><ArticleId IdType="pubmed">23499601</ArticleId></ArticleIdList></Reference><Reference><Citation>Ann Intern Med. 2016 Nov 1;165(9):617-624</Citation><ArticleIdList><ArticleId IdType="pubmed">27538259</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Microbiol. 2009 Nov;47(11):3454-60</Citation><ArticleIdList><ArticleId IdType="pubmed">19726603</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet Infect Dis. 2016 Aug;16(8):942-51</Citation><ArticleIdList><ArticleId IdType="pubmed">27061888</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2017 Aug 10;377(6):534-543</Citation><ArticleIdList><ArticleId IdType="pubmed">28792867</ArticleId></ArticleIdList></Reference><Reference><Citation>J Infect Dis. 2015 Sep 1;212(5):726-39</Citation><ArticleIdList><ArticleId IdType="pubmed">25784728</ArticleId></ArticleIdList></Reference><Reference><Citation>Euro Surveill. 2015;20(36):null</Citation><ArticleIdList><ArticleId IdType="pubmed">26535911</ArticleId></ArticleIdList></Reference><Reference><Citation>Pediatrics. 2016 Feb;137(2):e20153279</Citation><ArticleIdList><ArticleId IdType="pubmed">26738884</ArticleId></ArticleIdList></Reference><Reference><Citation>Expert Rev Vaccines. 2011 Aug;10(8):1131-41</Citation><ArticleIdList><ArticleId IdType="pubmed">21854309</ArticleId></ArticleIdList></Reference><Reference><Citation>Open Forum Infect Dis. 2017 Jul 24;4(3):ofx111</Citation><ArticleIdList><ArticleId IdType="pubmed">28852675</ArticleId></ArticleIdList></Reference><Reference><Citation>BMC Public Health. 2013 Jan 09;13:16</Citation><ArticleIdList><ArticleId IdType="pubmed">23302258</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Infect Dis. 2018 Feb 10;66(5):665-672</Citation><ArticleIdList><ArticleId IdType="pubmed">29029064</ArticleId></ArticleIdList></Reference><Reference><Citation>Can Commun Dis Rep. 2017 May 04;43(5):96-103</Citation><ArticleIdList><ArticleId IdType="pubmed">29770072</ArticleId></ArticleIdList></Reference><Reference><Citation>Arch Dis Child. 2018 Jan;103(1):101-105</Citation><ArticleIdList><ArticleId IdType="pubmed">28855230</ArticleId></ArticleIdList></Reference><Reference><Citation>MMWR Recomm Rep. 2016 Aug 26;65(5):1-54</Citation><ArticleIdList><ArticleId IdType="pubmed">27560619</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2009 Jun 18;360(25):2605-15</Citation><ArticleIdList><ArticleId IdType="pubmed">19423869</ArticleId></ArticleIdList></Reference><Reference><Citation>Vaccine. 2016 Jan 2;34(1):77-82</Citation><ArticleIdList><ArticleId IdType="pubmed">26589519</ArticleId></ArticleIdList></Reference><Reference><Citation>Euro Surveill. 2016 Sep 22;21(38):</Citation><ArticleIdList><ArticleId IdType="pubmed">27684447</ArticleId></ArticleIdList></Reference><Reference><Citation>BMC Pediatr. 2014 Aug 08;14:199</Citation><ArticleIdList><ArticleId IdType="pubmed">25102958</ArticleId></ArticleIdList></Reference><Reference><Citation>Vaccine. 2016 Mar 29;34(14):1672-9</Citation><ArticleIdList><ArticleId IdType="pubmed">26920469</ArticleId></ArticleIdList></Reference><Reference><Citation>Vaccine. 2017 May 9;35(20):2685-2693</Citation><ArticleIdList><ArticleId IdType="pubmed">28408121</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Canada</li></country><region><li>Alberta</li><li>Ontario</li></region><settlement><li>Calgary</li><li>Hamilton (Ontario)</li><li>Toronto</li></settlement><orgName><li>Université McMaster</li><li>Université de Calgary</li><li>Université de Toronto</li></orgName></list><tree><country name="Canada"><region name="Ontario"><name sortKey="Buchan, Sarah A" sort="Buchan, Sarah A" uniqKey="Buchan S" first="Sarah A" last="Buchan">Sarah A. Buchan</name></region><name sortKey="Booth, Stephanie" sort="Booth, Stephanie" uniqKey="Booth S" first="Stephanie" last="Booth">Stephanie Booth</name><name sortKey="Booth, Stephanie" sort="Booth, Stephanie" uniqKey="Booth S" first="Stephanie" last="Booth">Stephanie Booth</name><name sortKey="Buchan, Sarah A" sort="Buchan, Sarah A" uniqKey="Buchan S" first="Sarah A" last="Buchan">Sarah A. Buchan</name><name sortKey="Crowcroft, Natasha S" sort="Crowcroft, Natasha S" uniqKey="Crowcroft N" first="Natasha S" last="Crowcroft">Natasha S. Crowcroft</name><name sortKey="Crowcroft, Natasha S" sort="Crowcroft, Natasha S" uniqKey="Crowcroft N" first="Natasha S" last="Crowcroft">Natasha S. Crowcroft</name><name sortKey="Crowcroft, Natasha S" sort="Crowcroft, Natasha S" uniqKey="Crowcroft N" first="Natasha S" last="Crowcroft">Natasha S. Crowcroft</name><name sortKey="Drews, Steven J" sort="Drews, Steven J" uniqKey="Drews S" first="Steven J" last="Drews">Steven J. Drews</name><name sortKey="Drews, Steven J" sort="Drews, Steven J" uniqKey="Drews S" first="Steven J" last="Drews">Steven J. Drews</name><name sortKey="Kwong, Jeffrey C" sort="Kwong, Jeffrey C" uniqKey="Kwong J" first="Jeffrey C" last="Kwong">Jeffrey C. Kwong</name><name sortKey="Kwong, Jeffrey C" sort="Kwong, Jeffrey C" uniqKey="Kwong J" first="Jeffrey C" last="Kwong">Jeffrey C. Kwong</name><name sortKey="Kwong, Jeffrey C" sort="Kwong, Jeffrey C" uniqKey="Kwong J" first="Jeffrey C" last="Kwong">Jeffrey C. Kwong</name><name sortKey="Kwong, Jeffrey C" sort="Kwong, Jeffrey C" uniqKey="Kwong J" first="Jeffrey C" last="Kwong">Jeffrey C. Kwong</name><name sortKey="Kwong, Jeffrey C" sort="Kwong, Jeffrey C" uniqKey="Kwong J" first="Jeffrey C" last="Kwong">Jeffrey C. Kwong</name><name sortKey="Loeb, Mark" sort="Loeb, Mark" uniqKey="Loeb M" first="Mark" last="Loeb">Mark Loeb</name><name sortKey="Russell, Margaret L" sort="Russell, Margaret L" uniqKey="Russell M" first="Margaret L" last="Russell">Margaret L. Russell</name><name sortKey="Scott, Allison N" sort="Scott, Allison N" uniqKey="Scott A" first="Allison N" last="Scott">Allison N. Scott</name><name sortKey="Simmonds, Kimberley A" sort="Simmonds, Kimberley A" uniqKey="Simmonds K" first="Kimberley A" last="Simmonds">Kimberley A. Simmonds</name><name sortKey="Simmonds, Kimberley A" sort="Simmonds, Kimberley A" uniqKey="Simmonds K" first="Kimberley A" last="Simmonds">Kimberley A. Simmonds</name><name sortKey="Svenson, Lawrence W" sort="Svenson, Lawrence W" uniqKey="Svenson L" first="Lawrence W" last="Svenson">Lawrence W. Svenson</name><name sortKey="Svenson, Lawrence W" sort="Svenson, Lawrence W" uniqKey="Svenson L" first="Lawrence W" last="Svenson">Lawrence W. Svenson</name><name sortKey="Svenson, Lawrence W" sort="Svenson, Lawrence W" uniqKey="Svenson L" first="Lawrence W" last="Svenson">Lawrence W. Svenson</name><name sortKey="Warshawsky, Bryna F" sort="Warshawsky, Bryna F" uniqKey="Warshawsky B" first="Bryna F" last="Warshawsky">Bryna F. Warshawsky</name><name sortKey="Warshawsky, Bryna F" sort="Warshawsky, Bryna F" uniqKey="Warshawsky B" first="Bryna F" last="Warshawsky">Bryna F. Warshawsky</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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